Lisa was the woman with whom Vlad Tepes Dracula fell in love after becoming a vampire. After the death of his first wife, Vlad waited patiently for countless years, for he believed that she would one day be reborn so that they could be together again. When he met Lisa, he was convinced that she was his beloved reincarnated.

As the incorruptible Lisa learned to love him, Dracula's hatred toward God did not resonate onto her, because it was never in her nature to hate. In fact, she loved Vlad more than anything in the world despite his flawed vision.

To others, Lisa was known as the very kind woman who sacrificed all of her time to medicine; she would spend her days preparing all kinds of remedies for the sick and weary. Due to the paranoid nature prevalent in this time-period, when people lived in fear of the forces of darkness, a rumor spread that Lisa's medicinal practices were most effective because she was a witch. Thus, the authorities arrested her, tried her as a witch without much in the way of proof, and executed Lisa immediately thereafter. This was an act that drove Vlad to insanity and became the driving force behind his lust for revenge against the humans.

Though, there remained one true connection between the two: The baby to which Lisa gave birth shortly before her death--Adrian Farenheights Tepes, better known as Alucard. Right before her execution, she made Alucard promise to deliver to his father two messages: "Do not do the humans any harm," she'd ask, "for theirs is already a hard lot." Also, she needed that Vlad know one more thing: "Tell him," she said, "that I will love him for all of eternity."

In Symphony, Lisa's is more a pseudo-apperance: The Succubus tries to play upon Alucard's conflicted status by taking Lisa's form, in an attempt to manipulate him, to enrage him to the point where he'd join in evil's cause almost unwittingly (as in Luke Skywalker "joining the dark side"). The plan ended in failire, no doubt due to the nonjudgmental, clear-visioned traits Alucard inherited from his mother. After defeating Dracula in a painful confrontation, Alucard spoke to him Lisa's final words as he promised he would.